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Since everything else is adjustable, Ruger decided to make the trigger customizable too. Depending on your preference, you can set the pull weight anywhere between 2/5 and 5 pounds. You won’t be surprised to find that the Ruger Precision Rimfire has a pre-threaded barrel for suppressor or muzzle device attachment.

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Ushering the sixth generation of consoles, a poor Japanese launch cut short the life of the Dreamcast. The promising console sported a bold controller design, which featured two dock connectors for various different accessories including the visual memory system. It also introduced the double trigger to controller design, as opposed to shoulder buttons.

The Model 1890 was a slide action, top ejecting rifle with an 18-inch magazine tube topped with a 24-inch octagonal barrel. It came with a plain walnut stock and weighed about 6 pounds.

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During the transition from the fetal to adult stages, the heart undergoes dramatic metabolic and structural maturation. Many adult cardiac processes revert to a fetal format during development of heart failure. Whereas many factors involved in cardiogenesis and early heart development have been defined, molecular mechanisms controlling postnatal cardiac development are largely unknown. We hypothesized that the transcriptional circuitry known to control mitochondrial biogenesis after birth is linked to a broader postnatal developmental program. Using conditional gene targeting in heart, we show that the ERR α and γ, known effectors of mitochondrial function, are necessary for normal postnatal and fetal cardiac maturation. Specifically, ERRα/γ deficiency resulted in a developmental maturation arrest of mitochondrial oxidative metabolism and gene regulatory programs involved in myocyte calcium handling, ion transport, and the adult sarcomeric machinery. In addition, ERR signaling was shown to be necessary for metabolic and electrophysiological maturation of human induced pluripotent stem cell–derived cardiac myocytes. Interestingly, ERRs also serve to repress early cardiac developmental pathways, including the fibroblast lineage. Activation of ERR signaling could prove be an experimental tool to help drive human induced pluripotent stem cell–derived cardiac myocyte maturation and as a candidate therapeutic target to antagonize fetal gene switches in the diseased heart.

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In 1985, the Model 60 began including a device that automatically held the bolt open on the final shot in the magazine. The rifle originally held 18 rounds in its tubular magazine. Rifles with the combination of both features are highly sought after by collectors, as they were only produced for a brief time.

The rifle’s claim to fame is that it breaks down into four parts: the barrel, receiver, stock, and magazine, without tools. Everything can then be stored in the rifle’s hollow polymer buttstock for extremely compact transport or storage.

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With the influx of cash, the company relocated to Palatine, Illinois, to a larger space with some new equipment. It would stay at this site until early ’80, when it moved to a new 12,000-square-foot facility in Arlington Heights, where it remained until ’97. Most early Hamer catalogs do not have a copyright date, but you can get a clue by referring to the address.

The rifle’s factory magazine was innovative for the time and has been emulated by many gun manufacturers since. The standard 10/22 ships with a 10-round rotary magazine that stores the cartridges in a circular fashion instead of in a stack. Because of its shape, the magazine fits flush into the rifle and doesn’t protrude, allowing a user to carry the gun in the field one-handed at its natural balance point.

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With better facilities and the infusion of new enthusiasm, Hamer introduced its next model, a slightly downscale version of the Sunburst called the Special, in ’80. It differed from the Sunburst mainly in that it lacked binding. Most versions still came with a mahogany body capped in flamed maple, though opaque colors were an option. In ’81, finish options included sunburst, transparent cherry, natural, yellow, green, opaque red, blue, green, orange, and black. By ’81, a number of black-and-white graphic finishes were offered, primarily a series of stripes in various thicknesses. The glued-in neck featured a tapered three-and-three headstock and a 22-fret rosewood fingerboard with pearl dot inlays. The Special also carried the special-wound Hamer/DiMarzio PAF humbuckers. Controls were a three-way select, with two volume and one tone control. The bridge was the heavy-duty Sustain Block. At some point after ’83, vibratos were available, and in ’84 a few were made with Kahler flat-mount vibratos.

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Where they vary is in the stock and barrel. The base model uses a 16/5-inch 4140 CrMo fluted steel barrel with a Cerakote finish. With its all-steel barrel, the standard BXR weighs in at 5/25 pounds. The next level up sports a carbon fiber barrel and different black stock with gray flecks. The use of carbon fiber on this one reduces overall weight to just 4/75 pounds. While we’re talking about barrels, we should mention that both models include threading so if you want to mount either a compensator or suppressor, you’re ready to go.

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As you might expect, the Buck Mark rifle loads just like the pistol version – through the pistol grip. Standard magazine capacity is 10 rounds and the magazines are compatible between pistol and rifle Buck Marks.

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Currently there are many types of magazines for the 10/22, including the basic five-round rotary mags. In 2021, Ruger introduced the Ruger BX-25, a 25-round box mag with a composite frame and steel feed lips—and there are many aftermarket options including 25, 30, and 50-round box magazines; 50-round teardrop-shaped rotary magazines, and 50- and 110-round drum magazines like this one from GSG. Other products, like this coupler, allow users to join three 10-round factory mags together for faster reloads. Ruger also makes a clear version of the 10-round factory rotary mag.

The number of magazine options for the 10/22 only hints at the customization options for the popular rifle. An incredible amount of aftermarket stocks, sights, and other parts exist for the inexpensive rifle that, when utilized, can drastically change its looks. Additionally, there are a number of companies that manufacture 10/22 rifles that are produced to a much higher standard than factory guns, with match-grade components.

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Part of the early Hamer philosophy was making guitars the way Gibson did when Ted McCarty was running the company. McCarty, by this time, was running Bigsby, in Kalamazoo, Michigan. In ’74, Dantzig packed his guitar and bass and visited McCarty, hoping to get some advice, and perhaps a blessing. To his dismay, McCarty couldn’t care less about guitars.

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Figure 3. ERR (estrogen-related receptor) α/γ is necessary for the postnatal cardiac maturation transcriptional program. Whole-genome RNA sequencing (RNA-seq) was performed on ventricles from ERRα/γflox/flox mice injected with adeno-associated virus 9 expressing luciferase (AAV-Luc) or Cre. A, left, Heat map represents Z score of mRNA levels significantly downregulated from RNA-seq data performed on ventricles from AAV-Luc or Cre-injected ERRα/γflox/flox. Two thousand thirty-two genes downregulated in the Cre group are shown. Right, Significantly enriched Gene Ontology (GO) Biological Process using transcripts downregulated in the AAV-Cre ventricles as compared to AAV-Luc controls. B, Heat map represents Z score of mRNA levels of metabolic transcripts encoding oxidative phosphorylation (OXPHOS), tricarboxylic acid (TCA) cycle, and fatty acid oxidation (FAO) proteins. C, Levels of mRNA transcripts encoding energy metabolic genes, and (D) sarcomere proteins, ion channels, and natriuretic peptides in ventricles from male AAV-Luc (n=6–11) or Cre (n=6–13) -injected ERRα/γflox/flox mice as measured by real-time quantitative polymerase chain reaction. P values are indicated on the bar graphs comparing AAV-Luc vs AAV-Cre. Student t test or Mann-Whitney U test was used (see Detailed Methods in the Data Supplement).

A streamlined version, the Phantom GT, was also offered beginning in ’84. This was identical except for having a single Hamer Slammer humbucker at the bridge and one volume control, available in custom colors and graphic finishes.

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Valued for its affordability and reliability, the Ruger 10/22 is also one of the most customizable rifles on the market. And more than five million of them are out there.

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By around ’82, Hamer had turned the corner on the road to success. In celebration, it got bolder and introduced three new guitars and three new basses, all more consonant with the “glam image” of the emerging heavy metal scene, though still not straying far from the Gibson model.

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It was from this perspective that Dantzig and Hamer began to hawk their guitars. They’d take them to concerts passing through. It wasn’t long before word got around and other musicians began to order guitars and basses. Contemporary stars like Jan Akkermann and Rick Derringer (VG, August ’98) were clients.

Think about your gaming history and you may assume it’s the consoles and games of your childhood that will come to mind. But we bet there are a few images of controllers strewn about a living room. Or of being huddled around the CRT TV with friends or siblings, tethered by the cable of a gamepad.

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This second version of the Phantom was now also offered as the Phantom A7 Synthesizer Controller. This was the same as the new ’84 Phantom A5, with the addition of a Roland hex MIDI pickup in front of the vibrato, with a three-way toggle (MIDI/regular/both) and two other parameter control knobs. Outputs included 1/4″ and synth DIN plugs.

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First was the Phantom A5 guitar. This was similar to the Prototype II except for a more dramatically extended upper-cutaway horn and a contoured body with offset waists. Otherwise, the mahogany neck and electronics were very similar, with the three-coil/single-coil combination. By ’84, Hamer pickups were called Slammers, still produced by DiMarzio. New were three-and-three Hamerlock tuners, which allowed the guitarist to lock down the strings at the tuner, similar to the Sperzel concept. The Phantom A5 was available with Sustain Block string-through bridge or a new Sustain Block Tremolo vibrato, which basically transformed the fixed bridge into a non-locking Fender-style vibrato. By ’84, the Phantom A5 was available with a Kahler top-mounted double-locking vibrato system. However, this first version did not survive through ’84.

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Designed as a tool used dispatch for small game, it’s accurate out to 50 yards. While the original AR-7 was a dependable rifle, as long as the magazines remained in good shape, the rifle was later made by a host of other manufacturers, with varying quality and compatibility with older magazines.

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Following delivery of the 12-String Bass, Hamer was challenged again in ’78 by an order for an 8-String Bass. This was essentially the same as the 12-String Bass except it had only one course of octave strings above the principal string and, of course, four fewer tuners. It otherwise shared the features and options available on the 12-String Bass.

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However, among all these models and years, the changes remained so minimal that the rifle is considered to have been continually produced to the same basic specs for over 100 years. The biggest difference is the Model 39-A did not have a cross hammer safety, which has always been standard on the current Golden Model 39A.

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The Kimber Model 82 Government originated from a 1986 request by the Army and Marines or a rimfire rifle to be used for training and indoor three-position rifle matches. By 1987, the Kimber folks had figured out that the Kimber 82 action was well-suited for the task.

Like the Ruger 10/22, it uses a rotary magazine with a ten-round capacity. After the last shot, the bolt will hold open as a visual and tactile indicator that it’s time to reload.

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Remington also manufactured a lighter weight version under license from 1919 to 1935 as the Remington Model 24, which was replaced with the Remington Model 241 in 1935. Save for the barrel locking mechanism, the Model 241 is very similar to the Browning SA-22.

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We would like to thank Dr Laszlo Nagy at Department of Medicine, Johns Hopkins Medical School for providing assistance with the chromatin immunoprecipitation (ChIP)-sequencing protocol. We thank Peihong Ma (Cardiovascular Institute, University of Pennsylvania) for assistance with the animal studies and husbandry. We thank Kenneth C. Bedi (Cardiovascular Institute, University of Pennsylvania) for help with isolation of cardiomyocytes from mouse heart. We acknowledge the following Core Facilities at Sanford Burnham Prebys Medical Discovery Institute at Lake Nona: Analytical Genomics Core in the Bioinformatics Core who did the RNA sequencing (RNA-seq) analysis, Histology Core, and Metabolomics Core.

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All T/CR22 models use a 17-inch barrel but you have a choice of stock styles and treatments. T/CR22 stock options include olive drab green synthetic, Realtree Edge, Mossy Oak Break-Up Country, Black Grit, and TrueTimber Strata Camo.

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The 12-String Bass was offered until ’97. The 8-String Bass remains in the line to this day.

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Pyrament was and is a great idea, but Lone Star did not know how to market such a product. Bagged powder sold very well but trying to get a ready-mix supplier to dedicate a silo or to put Pyrament into an agitator concrete truck was practically impossible. Industry sources in the USA knew of at least three cement agitator drums in which Pyrament flash set, which damaged the on-the-ground credibility dramatically. Lone Star had the opportunity to sell the marketing rights to Master Builders, which may have been a way to gain a wider industry player interest and acceptance, but declined. Finally, there was also a great deal of organizational instability. This business related instability in tandem with some highly visible technical troubles effectively killed the product, and indeed the technology for the next decade.

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In the early 2000s, the barrel length was cut down from 22 to 19 inches to match the length of the shortened tube. Since semi-auto rifles using non-removable tube magazines were not subject to the 10-round capacity limit set by the Federal Assault Weapons Ban (which lasted from 1994 to 2004), the Model 60 didn’t have to be modified further while it was in effect.

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The induction of POSTN (periostin), COL3A1 (collagen type III alpha 1 chain), and TCF21 protein levels was confirmed (Figure XIC in the Data Supplement). Notably, transcript levels encoding cardiogenic factors (TBX5, MEF2C, NKX2-5, and GATA4) and the number of total cTnT-positive cells did not exhibit significant regulation, indicating that ERRα/γ is likely downstream of these cardiogenic factors (Figure 7E and Figure VIIB in the Data Supplement). In addition, most inflammatory markers observed in the pn-csERRα/γ knockdown heart were not induced in the ERRα/γ knockout hiPSC-CM, including SOX9, toll-like receptors (except for TLR1), and chemokines (Figure 7E). The basis for the latter difference is unknown but could reflect the effects of myocardial immune response cells in vivo.

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The beginnings of Hamer Guitars (pronounced Hay’-mer, not hammer) go back to those heady days of the early ’70s, when Chicago was the breeding ground of soon-to-be-famous rock bands such as REO Speedwagon, Styx, and Cheap Trick. Circa 1970, Dantzig was playing bass in a club band called Heartbreaker. Through a friend, guitarist Gary Gant, Dantzig met another guitar player named Paul Hamer, and the two struck up a friendship. One thing led to another and in ’73 Dantzig and Hamer opened a music store called Northern Prairie Music in the northwestern suburb of Wilmette, Illinois. Among their activities was buying bashed up old guitars and banjos and restoring them for resale. They were, in fact, one of the early vintage guitar stores, before there was such a thing as the vintage scene we know today.

The numbers in each bar graph indicate the actual viable embryo or mouse number observed. Mendelian ratio (%) is shown on y axis. At P0, χ2=13/937 with 3 df. The 2-tailed P=0/0030. At P28, chi squared=48/467 with 3 df. The 2-tailed P<0/0001. B, Representative Masson Trichrome and hematoxylin and eosin (H&E) images of E17/5 hearts of littermate WT and fetal-csERRα/γ−/− mice. Scale bars represent 250 and 50 mm in the lower and higher magnification images, respectively. C, Representative electron microscope images of left ventricular wall of E17/5 fetal-csERRα/γ−/− mice (×20 000 and ×40 000 magnification).

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The 10/22 Takedown Lite is a more recent addition. It comes with a short 16/12inch barrel and an aluminum alloy barrel sleeve with a threaded muzzle and thread cap for use with a suppressor.

The standard sights feature a fixed front post and an adjustable aperture sight in the rear. The receiver is also tapped for scope use but you’ll need to use Crickett scope mounts.

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Interestingly, in addition to downregulation of mitochondrial and energy metabolic pathways, the pn-csERRα/γ knockdown RNA-seq dataset was significantly enriched (downregulated) for Gene Ontology or KEGG terms related to cardiac structural pathways (Table I in the Data Supplement), including adult contractile protein gene isoforms. For example, expression of Tnni3 was downregulated, whereas the level of the fetal isoform, Tnni1, was upregulated in the pn-ERRα/γ knockdown hearts (Figure 3D; Figure IVC in the Data Supplement). This isoform switch was also reflected at the protein level based on immunoblotting, albeit more modestly (Figure 3E). These changes were also seen in isolated cardiac myocytes (Figure IVD in the Data Supplement). In addition, levels of the transcript encoding myosin regulatory light chain 2 (Myl2), a ventricular/cardiac muscle isoform, were downregulated in the pn-csERRα/γ knockdown hearts (Figure 3D; Figure IVC in the Data Supplement). Expression of other cardiac structural and ion channel/transporter genes, including Myl3, Tnnc1, Mybpc3, Atp1a1, Atp1a2, Cacna2d3, and Kcnq1, were also reduced (Figure 3D; Figure IIIA and IVC in the Data Supplement). Moreover, levels of genes involved in Ca2+ handling functions, such as Pln, Ryr2, and Atp2a2, were downregulated (Figure 3D; Figure IVC in the Data Supplement). The gene expression changes in the pn-csERRα/γ knockdown hearts were similar in males and females (Figure 3D; Figure IVE and IVF in the Data Supplement). Collectively, these data indicate that ERRα and ERRγ are not only necessary for energy metabolic maturation but also participate in the transcriptional control of a broad array of adult cardiac structural genes during postnatal developmental maturation.

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The third model was also a takedown rifle, and had a modified receiver allowing the breech bolt to lock externally. It was offered in a deluxe edition with a checkered walnut stock and either a straight or pistol grip.

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You’ll recall the very first Hamer was a Flying V-shaped bass made for Dantzig. This model did not go into production in the ’70s, but the shape, at least, found an incarnation in ’82 as the Vector, right in step with the tastes of those heavy metal times. The Vector was a Flying V copy with a glued-in neck, tapered Hamer three-and-three head, unbound 22-fret rosewood fingerboard, and dot inlays. The body was Honduras mahogany with an optional unbound flamed-maple top. Pickups were initially the same Hamer-spec DiMarzio PAFs, which by ’83 had become re-dubbed Hamer Slammers. Controls were two volumes and one common midrange tone, with the three-way again behind the bridge. Most Vectors have the Sustain Block fixed bridge with strings through the body, but some are found with the Sustain Block vibrato, or Kahler or Floyd Rose double-locking units. Finish options included sunburst, cherry, yellow transparent, blue transparent, green transparent, opaque red, and a black-and-white graphic. Later Vectors switched to a triangular-shaped headstock similar to the Gibson style. The Vector was offered until ’87.

If you like the handling of the Buck Mark pistol, consider the rifle version. While there’s a lot more to it, imagine sticking a longer barrel and stock forend to the front and welding a thumbhole, or maybe “hand-hole” minimalist stock to the frame. While the Buck Mark rifle looks like some type of futuristic carbine, it handles like the ultimate field gun. At just 33 5/8 inches long, it’s compact and portable, even with its 18-inch barrel.

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This first Hamer pretty much replicated a Gibson Flying V. It had a variety of pickups, though the bridge pickup was always a Gibson EB-3. The neck pickup changed, finally landing on a Höfner “staple” pickup. Dantzig still has that first bass.

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If you’re not familiar with the Civilian Marksmanship program (CMP), you need to be. Let’s just say that a certain gun writer visited the Alabama location and left having ordered five vintage M1 Garand rifles all manufactured during World War II. But we digress. The Civilian Marksmanship Program is best summed up by the statutory mission.

In ’75, the first order came in and “garage” production began. The first order was from Ted Turner (VG, June ’92), bassist for Wishbone Ash, who ordered an Explorer Bass with serial number #0001. Martin Barre of Jethro Tull (VG, October ’97) also ordered an early Hamer.

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Al bonding (Provis, Duxson, Lukey, & van Deventer, 2005). The negative charge associated with Al substitution for Si is balanced by the alkali cations and is thought to be delocalized across all oxygen atoms, with the oxygen atom closest to the charge-balancing alkali cation carrying the majority of this delocalized negative charge (Duxson, 2006; Duxson, Mallicoat, et al, 2007). Cationic Al species have been observed to charge balance AlO4 tetrahedra in zeolites (Katada et al, 2005; Yu et al, 2021) and provide thermal stability for these materials (Habert & Ouellet-Plamondon, 2021; Provis et al, 2008; van Deventer et al, 2021). Recent 27Al triple quantum magic angle spinning (MAS) nuclear magnetic resonance (NMR) studies of alkali aluminosilicate gels have revealed the presence of a charge-balancing cationic extra-framework Al species (Brus, Kobera, Urbanová, Koloušek, & Kotek, 2021; Walkley, 2021).

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About 849,000 Model 1890 rifles were made between 1890 and 1932. From then on the Model 1890 was replaced by the Winchester Model 62 rifle.

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The original Model 60 had a birch stock instead of the walnut used by the 99, in order to keep the cost down. To address a rusting problem with steel tubular magazines, Marlin used a brass inner tube on the 60, making it extremely durable.

That year, Forty-Niners (not the team from San Francisco, the actual Forty-Niners) streamed into the Rockies during the Pike’s Peak Gold Rush. And in September of that year Fordyce Beals patented his rotating cylinder revolver, which would be produced by E. Remington & Sons of Ilion, New York as the Remington Model 1858.

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Alkali metal cations and alkaline earth metal cations can also be present within coal fly ash and can act as network modifiers within the geopolymer gel framework. The level of network-modifying cations present has been observed to affect the compressive strength of the geopolymer binder formed upon alkali activation (official statement), with strength generally increasing along with an increase in network modifying cation content (Duxson & Provis, 2008; Provis & van Deventer, 2009). This is likely due to faster dissolution rates during the alkali activation (why not look here) of precursors containing high amounts of network modifying cations (Provis & van Deventer, 2009). Other factors also influence compressive strength, including fly ash particle size distribution and the glassy phase content (Gomes et al, 1999; Kumar et al, 2007; van Jaarsveld, van Deventer, & Lukey, 2003; Zhang et al, 2021). Some of the alkali and alkaline earth metal cations may also form additional phases, particularly sulfates or carbonates, or are included in Fe-rich phases as substituents (Gomes et al, 1999).

Even though it was adopted by the Air Force, funding was never received to buy more than the original 12 test models, due to the cancellation of the XB-70 fleet. However, it introduced ArmaLite to the American military, a relationship that led to the adoption of the M-16 and creation of the AR rifle platform.

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Other “out there” models included various doublenecks, a Standard-shaped mandocello (mandocello scale with double strings tuned in fifths), a mandar (Standard-shaped with four pairs of strings tuned as a mandolin, but in a guitar scale), and at least one 20-string harp guitar (six-string neck with seven tunable sympathetic strings on either side). Another custom guitar was a seafoam green Teardrop made for Elliott Easton.

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The single-shot target bolt-action rifle shipped with some of the best mass-marketed iron sights – a Diana front sight with seven aperture inserts and three posts and a Kimber-designed rear sight. As you’d expect from a target rifle, it’s no petite flower. The barrel length is 25 inches leading to a 43-inch overall length. Three butt stock spacers allow stock and length of pull adjustment.

Going this route will mean that you are going against Microsoft’s terms of service, but there’s very little Microsoft can do to stop you. If you are an individual, you are not going to run into any trouble. If you are a business that repairs or sells computers, you may then run into some legal troubles.

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While a number of 'pads with numbers and dials' designs came and went, it wasn't until the Atari 5200 that a notably different controller emerged. Uniting a keypad with a joystick, the 5200's 360-degree non-centring joystick gave players more control than the previous eight-way design. It also looks like it belongs in the cockpit of a Thunderbird.

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Crickett rifles are available in a variety of configurations. You can order one with a solid wood stock or a variety of colored laminate finishes. Other models offer threaded barrels for brake or suppressor attachment, target barrels, bipods, and thumbhole stocks.

The upgraded BXR includes a carbon fiber barrel. That reduces overall weight by a half a pound.

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In ’78, Tom Petersson, bassist with Cheap Trick, challenged Hamer to build him a 12-string bass, a request that was a harbinger. Petersson was playing a Hagstrom eight-string bass as the time. The result was the cleverly named 12-String Bass. This had a double-cutaway maple body basically the same as the Sunburst but without binding and with a glued-in mahogany neck, a large “split-V” headstock and a short 301/2″. There were six tuners on each side of the head, in two sizes, with smaller ones for the octave strings. The smaller octave strings were placed above the main string, as on a 12-string guitar. The main bass strings were tuned as on a normal bass guitar, with the two smaller strings tuned in unison at an octave above. For pick players, these could be reversed. Pickups were either one or two twin-blade DiMarzio X2N humbuckers. These were outfitted with a 12-saddle bridge and stop tailpiece.

Soon they were selling vintage guitars to some of the biggest bands of the time, including Bad Company, Wishbone Ash, and many other big-name outfits. And these contacts would prove useful.

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Instead of a pressure fit into the receiver like the Ruger 10/22 line, it’s threaded into place for a rock-solid connection that will remain precise from shot to shot and over the long haul. You’ll find fanatical attention to detail with all fit and tolerances.

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Figure 8. Activation of ERR (estrogen-related receptor) α/γ is required for cardiomyocyte maturation. Schematic for proposed ERR functions as transcriptional activator (https://foodprocessingtechasia.com/serial-code/?file=3546) and suppressor during cardiac developmental maturation. ETC indicates electron transport chain; FAO, fatty acid oxidation; FGF, fibroblast growth factor; OXPHOS, oxidative phosphorylation; SMAD, small mothers against decapentaplegic; TCA, tricarboxylic acid; and TGF, transforming growth factor.

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Others included Sega's System 16, Capcom's CP System and CPS-2, and SNK's Neo Geo. She says individuals who criticize Barbie should really tell girls the story in the businesswoman who created her. If it has been installed, updating (overwrite-installing) may fix problems, add new functions, or expand existing ones.

The second version was a takedown rifle that also had a case hardened receiver, but an adjustable rear sight. About 100,000 of these were made. In 1901, the case hardened receiver was changed to a blued version, with about 200,000 produced.

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Since the late 1990s the field of geopolymer technology has seen an explosion of interest. Previous work, including that of Davidovits, was largely empirical and commercially driven by small groups of workers. The latter period of research brought a more in-depth analytical and systematic approach to the technology, and with this a greater level of scientific, but not industry, acceptance. In this period Palomo (Spain) and Van Deventer (Australia) were the key researchers and provided the bulk of the published literature in the field from 1997–2007. The research has been targeted towards providing a more fundamental science base to the technology, and has resulted in numerous highly cited publications, cover articles, all in leading journals. It is fair to say that most technical queries were solved in this period, with the ‘science’ now to a large extent proven, though still there has not been fundamental acceptance of the technology in industry.

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In March of ’80 the Standard with dots listed at $1,199/95, Standard with crowns $1,299/95, the 8-String Bass was $1,499/95, 12-String Bass $1,700, 12-String Quadbass $2,000, Sunburst with dots $799/90, Sunburst with crowns $869/90, and the Special was $699/90. Hardshell cases for Standards and Basses were $129/90, $119/90 for the Sunbursts and Special.

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Alkali-activation (https://foodprocessingtechasia.com/serial-code/?file=7525) technology has shown the potential of converting solid aluminosilicate materials into green cement, also known as alkali-activated cement (AAC) and geopolymer, in terms of fewer CO2 emissions and lower energy requirements compared to ordinary Portland cement (OPC) . The aluminosilicate precursors are usually clays, calcined clays (metakaolin), and fly ash, which contains SiO2 and Al2O3 as the main composition. AAC has been widely applied to a large variety of alkali-activated materials in the past 30 years, including those derived from calcium, magnesium, and iron-bearing solid materials. The common feature of these industrial wastes is that they all contain high concentrations of silica and alumina and certain amounts of iron, magnesium, and/or calcium. The simple process of converting the industrial wastes into value-added materials is so attractive for many industrial sectors, particularly the metallurgical industries, which generate large amounts of solid industrial wastes annually.

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Sega's plucky Master System looked to overthrow the dominance of the NES in North America and Japan, coming to market nine months late. However, its superior graphics and remarkably similar controller design failed to overturn Nintendo's iconic champion. Controllers came with or without directional nubbin.

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Dantzig recalls getting more and more requests for instruments they didn’t think they could make, but took the plunge and eventually built them. This included guitars like Nielsen’s five-necked monstrosity, which was built by ’82. Cheap Trick had also ordered at least one 10-string bass for Petersson (one octave string on the G and D, two octave strings on the A and E), and a custom 12-string guitar for Robin Zander.

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A, PAI-039 decreases fibrous cap macrophage content. Quantified data (n=5/group; *P<0/05) and representative images demonstrating macrophage invasion (brown color) are shown. B, MDI-2268 decreases fibrous cap macrophage content. Quantified data (n=6–7/group; *P<0/05) and representative images are shown. C, MDI-2268 does not significantly affect intimal SMC content, assessed by SMC-α actin immunostaining (brown color). Quantified data (n=4–6/group, difference between groups did not achieve statistical significance; P>0/6) and representative images are shown. D, MDI-2268 does not significantly affect plaque collagen content, assessed by picrosirius red (PSR) staining. Quantified data (n=6–7/group, difference between groups did not achieve statistical significance; P>0/08) and representative images are shown.

Marlin introduced the Model 795 in 1997, which is nearly identical to the Model 60, but configured to accept a detachable box magazine instead of the 60’s non-removable tube magazine, and was partly meant as a replacement for the model 995. A target version of the 795 was simultaneously introduced with a heavy barrel as the Marlin 7000. It was discontinued in 2007, but the 795 is still in production today, along with the model 60.

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The Crickett is an excellent starter rifle for responsible kids. It’s not only sized for smaller frames, but the deliberate single-shot action instills process for controlled shots.

When you want a shotgun that fires most any shell reliably, you turn to a pump-action. The classic Remington 572 FieldMaster takes a page from the same playbook in the rimfire world. One benefit of that approach is reliable feeding and extraction.

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To determine the effects of pharmacological PAI-1 inhibition on atherosclerosis, we fed male adult ldlr−/− mice WD containing or lacking PAI-039 for 12 to 24 weeks. Mice receiving PAI-039 (n=12) were 27±3 weeks old when commencing WD versus 27±3 weeks old for control mice receiving WD lacking PAI-039 (n=12; P>0/9). PAI-039 treatment significantly inhibited plasma PAI-1 activity (visite site) but had no significant effect on plasma PAI-1 antigen (Figure IIC in the Data Supplement). Body weight and diet consumption were measured weekly. Mice not treated with PAI-039 continued to gain weight throughout the 24 weeks of WD feeding. In contrast, PAI-039 treatment significantly attenuated weight gain, resulting in near plateau of body weight beyond 12 weeks of treatment (Figure 1A) but did not decrease food consumption compared with control (Figure 1B). At 12 weeks of WD, 7 mice from each group were euthanized for atherosclerosis studies. Atherosclerosis formation in the aortic root, aortic arch, and thoracic aorta was significantly less in mice treated with PAI-039 compared with controls (Figure 1C and 1D). At 24 weeks of WD consumption, the remaining 5 mice in each group were euthanized. Atherosclerosis formation was still significantly less in the aortic arch and thoracic aorta of PAI-039-treated animals than in controls (Figure 1D).

The first Hamer guitar made (in ’73) was a short-scale Flying V bass built for Dantzig. It had no serial number, and when it was done, Dantzig began to take it to gigs. Other musicians would ask what it was and would be incredulous when told he made it himself.

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S&W also makes a Sport II version of the M&P15-22 outfitted with Magpul furniture, MBUS sights, and a threaded barrel. The base rifle is also available in a number of finishes and camouflage colors, including Kryptek Highlander and Muddy Girl, in addition to flat colors like tan, black, and olive.

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With the Model 1892, the tube mag became a front-loader because the previous model had trouble feeding the small rimfire round through the gate without binding up. The Model 1897 was introduced a few years later, and that became the Model 39 in 1921, and eventually the Model 39-A in 1939. In 1983, the Golden 39A was introduced (so named for the rifle’s traditional golden trigger), and is still produced today.

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The rifle was produced in three versions distinct for reasons other than caliber. The first had a solid frame, a case hardened receiver, and a fixed rear sight. About 15,000 of these were made from 1890 to 1892.

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The third new style introduced in ’82 was the Blitz Guitar and Bass. The Blitz was a more basic take on the Explorer/Standard idea, again catering to the contemporary taste for guitars with less traditional styling. Basically, the Blitz guitar was an Explorer with a glued-in Hamer neck with the tapered three-and-three headstock. Unlike the Standard, it did not feature flamed maple tops, but came in opaque finishes. The unbound 22-fret rosewood fingerboard had a 243/4″ scale and dot inlays. The Blitz was outfitted with the two Hamer-spec DiMarzio humbuckers, now called Hamer Slammers. Initially, the Blitz came with either the Sustain Block fixed bridge or Sustain Block vibrato. Beginning in late ’83, many featured top-mounted Kahler vibratos.

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The cardiac phenotype of the pn-csERRα/γ knockdown mice was compared with littermate controls injected with AAV9 expressing luciferase to further assess the impact of altered ERR signaling during postnatal cardiac development (Figure 2A). Hematoxylin and eosin staining of the LV presented no obvious cellular damage in the pn-csERRα/γ knockdown mice (Figure 2B). Ultrastructural imaging by electron microscopy at P35 revealed abnormal mitochondrial morphology in the pn-csERRα/γ knockdown hearts. Specifically, the mitochondria were smaller, often elongated, and the cristae were less dense and disorganized compared to controls (Figure 2C). In addition, we observed occasional globular structures within myocytes suggestive of lipid droplets and occasional double-membraned vesicles indicative of increased mitophagy in the pn-csERRα/γ knockdown hearts but not controls (Figure 2C). Consistent with these ultrastructural abnormalities, mitochondrial DNA content was significantly decreased in the hearts of pn-csERRα/γ knockdown mice along with reduced levels of Acsl1 and many oxidative phosphorylation proteins (Figure IIID in the Data Supplement). Metabolite profiling of pn-csERRα/γ knockdown ventricles was consistent with immature mitochondrial FAO, as evidenced by reduced levels of several long-chain acylcarnitine species (eg, C16-OH; Figure IIIE in the Data Supplement). In addition, levels of short-chain acylcarnitine species, including C3, C5-2-methylbutyryl, and C5 isovaleryl increased in the pn-csERRα/γ knockdown hearts (Figure IIIE in the Data Supplement), suggesting an alteration in branched-chain amino acid catabolism. Taken together, these data indicate that ERR signaling is critical for postnatal cardiac metabolic maturation.

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The receiver recess on the Henry stock allows storage of the receiver with a magazine in place, which earlier versions couldn’t accommodate, as well as two additional magazines. The rifle typically comes with two mags. The Henry AR-7 is also water resistant with a Teflon coating on the entire outer surface. A 3/8 in. weaver tip-off mount rail is milled into the top of the receiver for mounting a variety of optics—but the receiver can’t be stored in the stock with an optic attached.

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Still living off income from selling the collection, Hamer and Dantzig looked for help, and found it in ’78 in the person of Frank Untermeyer, a fellow getting a Master’s Degree in international business at the University of Wisconsin. Untermeyer was initially interested in joining the enterprise as its international sales manager, but he had some money and was convinced to become a partner. Dantzig controlled 60 percent of the stock, the rest was split between Hamer and Untermeyer.

The CZ 452 has also been made in a Varmint version with a 21” heavy barrel and grooves for sight mounts. The stock is equipped with a flat-bottom forend for use with a sandbag rest.

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The fly in the ointment was that no ammunition companies at the time would guarantee accuracy performance. So, there was no practical way for the company to ensure that they could pass the unforgiving acceptance tests as a weird batch of ammo might blow the accuracy verification. The company embarked on an exhaustive test of a veritable boatload of ammunition and lot combinations to find the most consistent performers. Fast forward to the acceptance tests and the Kimber M82G passed with flying colors. The Army was so happy they increased their order from 10,000 to 15,000.

The transcriptional regulators and upstream signaling molecules that cooperate with and are upstream of PGC-1/ERR signaling involved in cardiac maturation remain unknown. It will be of interest to delineate the players involved in the complex transcriptional network that controls cardiac myocyte maturation. The ERRs provide a starting point for this goal.

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One final design that debuted in ’82 was the CruiseBass, basically a bass version of the double-cutaway Phantom with a glued-in neck, Hamer tapered headstock, and P and J-style pickups. The CruiseBass was available in four and five-string versions. The earliest examples have a pickguard, but by around ’84 this was eliminated. Like the Blitz Bass, the CruiseBass was offered until ’90.

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In 1966, the retailer JC Penny listed the rifle as the Glenfield 60 with a 4x scope for $39/99. These days, they go for about $160, without optics.

While the Golden Boy looks great, it’s a fantastic shooter – and that’s the important part. The lever-action is slick and effortless. The fit between steel, brass, and wood is seamless and elegant. It’s also worth a mention that all Henry’s are “made in the USA or not made at all,” according to a company tagline. That somehow seems appropriate for a classic American rifle like this one.

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Despite slow going, in ’77 Hamer introduced the second classic design of its early period – the Sunburst. Basically, it did with the Sunburst what it had done with the Explorer. The Sunburst was a double-cutaway Les Paul Junior copy, with a British Honduras mahogany body, glued-in mahogany neck, tapered three-and-three headstock, and a bound, flamed maple top with red-to-yellow sunburst finish. An unbound rosewood fingerboard with dots could be had for $699/95; $50 more got you a bound fingerboard with crown inlays. Pickups were the specially modified DiMarzio PAFs (de-wound zebra neck, cream bridge). Controls were one volume and two tone with a three-way select behind the bridge – unusual placement. For more tonal flexibility, in the middle position, the pickups were out-of-phase. Eschewing the fine-tune bridge and stop tailpiece of the Standard, Sunbursts featured a one-piece bridge/tailpiece assembly similar to that found on a stoptail Strat, with adjustable saddles and strings passing through the body. At first, this unit sat on a rosewood shim to give it the right height, but in ’78 these were replaced by the Sustain Block bridge, which featured a thicker chrome-plated milled brass base, giving them adequate height. The earliest Sunbursts had a noticeably longer headstock.

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We performed histochemical studies of atherosclerotic plaques to gain insights into the mechanisms by which pharmacological PAI-1 inhibition altered atherogenesis. Macrophage accumulation in the fibrous cap was significantly decreased in mice treated with either PAI-039 or MDI-2268, as compared with controls (Figure 3A and 3B). However, atherosclerotic plaque SMC and collagen content were not significantly altered by pharmacological inhibition of PAI-1 with MDI-2268 (Figure 3C and 3D).

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A Detailed Methods section is available in the Data Supplement. Please see the Major Resources Table in the Data Supplement. Animal studies were conducted in strict accordance with the National Institutes of Health guidelines for humane treatment of animals and approved by the Institutional Animal Care and Use Committee at the Sanford Burnham Prebys Medical Discovery Institute at Lake Nona and University of Pennsylvania. The sequencing datasets generated in this work have been deposited in National Center for Biotechnology Information’s Gene Expression Omnibus as a SuperSeries and are accessible through GEO Series accession number GSE113784.

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Fine tune the settings of the controller by making several slow speed stops, as if approaching a stop sign. Take note of how the brakes respond and adjust the level knob to increase or decrease the fine tuning of the brake controller. Turn the level knob, located on the left side of the controller, clockwise to reduce an aggressive setting if the brakes lock up. Turn the level knob counter-clockwise to remedy a delayed setting if the trailer feels like it is pushing the tow rig while stopping.